Explore the discovery, the biology, and the clinical evidence behind Prologue
THE DISCOVERY
“We identified the biological pathway responsible for pigment loss, and, more importantly, how to block it.”
Many great discoveries begin by accident. While advancing novel approaches to tissue regeneration, our team stumbled upon a mechanism at the root of hair whitening.
For the first time, we could not only halt the graying process — but potentially reverse it, restoring natural pigmentation from the follicle up.
WHAT SETS US APART
the science of graying
Hair color originates deep in the skin, at the stem cell level.
Deep within lies the biological engine room of your hair. Two populations: hair follicle and melanocyte stem cells.
Melanocyte stem cells are the first to fail. Some go dormant, others undergo apoptosis. When they fail, no pigment is produced, and hair turns gray.
MEET THE CO-FOUNDER
Dr. Yaron Fuchs
Co-Founder & Chief Scientist · Prologue
“The hair follicle is one of the most extraordinary regenerative systems in the human body. We just needed to learn how to speak its language.”
An award-winning stem cell biologist, Dr. Fuchs discovered a specific pathway directly responsible for hair graying, and a way to interrupt it at the molecular level.
That discovery became the foundation of Prologue and led to NeoStemix™, a novel biomimetic peptide system designed to maintain natural hair color and defend against pigment loss.
Award-winning stem cell & apoptosis researcher
Two Helsinki Committee approvals for human tissue research
NeoStemix™ patented
Multidisciplinary team spanning 6 scientific fields
THE INNOVATION
A family of novel biomimetic peptides, precisely engineered molecules that mimic natural proteins in the pigmentation pathway. Created using AI-driven molecular modelling and crystallographic structure analysis.
Selected Publications
How stem cells survive, how cells communicate, and how tissues regenerate—selected findings from our team’s academic research
Developmental Cell · 2021
Research in mice showing how cells undergoing programmed cell death can send signals that influence stem cell proliferation and tissue regeneration.
Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration
Read publicationNature Communications · 2022
Identifies a population of stem cells in mouse skin that contributes to long-term tissue maintenance and wound repair.
Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis
Read publicationNature Communications · 2023
Explores how changes in cell-death regulation affect competition between hair follicle stem cells and tissue regeneration in mice.
Apoptotic dysregulation mediates stem cell competition and tissue regeneration
Read publicationRESEARCH PLATFORMS
Freshly excised living tissue. The stem cell niche studied in its native biological state. No substitutes.
Full human scalp tissue, to verify our technology.
Human tissue research follows Helsinki Committee approvals and ethical guidelines
CLINICAL RESULTS
FULL COHORT
34 participants
showed stable or reduced visible graying
100%
showed deeper or more even pigment tone
35%
Scalp regions showed re-pigmentation
100%
Note: Before & after images are illustrative representations of participant hair color changes. Individual results may vary.
Re-pigmented
New growth at the root
